Virus of lymphocyte of T of human be addicted to 1 model (HTLV-1) calls leukaemia of human T cell virus again, can cause leukaemia of adult T cell / lymphatic tumour (ATL) . In addition, have multinomial research report, a variety of malignant tumor besides HTLV-1 infection and ATL come on dangerous heighten is relevant. But, japan has a scholar to publish a paper to say however, this virus infection can reduce cancer of the stomach to send sick into death danger.

To the dependency of HTLV-1 infection and malignant tumor, different learned man has different view. For example, japanese hemp is unripe (the report such as Asou) , this virus infection and a variety of cancer risk heighten are relevant, have lustre (Arisawa) think, outside dividing cancer of rectum of ATL, knot, lung cancer, liver cancer, this virus infection won't bring any other cancer to send sick into death danger. As contrary as this, also have scholastic report, to cancer of the stomach, this virus infection restrained his to come on it seems that, japan has plain the pine of the hospital this (Matsumoto) hold this kind of point of view.

　　 The person that is HTLV-1 affected " a fault on the right side " ?

Recently, the report such as Matsumoto, HTLV-1 infection can reduce cancer of the stomach to come on it seems that odds, its paper has been in " contagion magazine " on publish.

There already was a data to show before this, japan has plain incidence of a disease of area resident cancer of the stomach is inferior, and HTLV-1 positive rate is remarkable taller. To make clear HTLV-1 infection and cancer of the stomach come on the dependency between, matsumoto had a research.

This research brings into 5686 40 years old in all above suffers the person that try. These suffer the person that try to be in 1989-1992 year sufferred serum HTLV-1 antibody to detect secondhand, after this, the person that investigator tries to all sufferring undertakes following till,be visittinged in March 2003. Be in along with during visitting, 1812 accepted gastroscope inspection. Suffer in these in the person that try, 497 enter the positive of eventuate of HTLV-1 serological examination that scrutator of cancer of the stomach did not accept when the group, among them the male 183, female 314, average age is 59 years old. Additionally 497 are entered cancer of the stomach was not accepted to check when the group but HTLV-1 suffers the person that try electronegatively to be set to be collator, their age, sexual distinction, along with visit time all with before the person that narrate HTLV-1 positive matchs.

The result shows, in HTLV-1 positive person in, 14 (2.8%) happening cancer of the stomach, and HTLV-1 is electronegative person have 35 (7.0%) happening cancer of the stomach, ratio is compared (OR) is 0.38(P=0.0028) . From this, investigator thinks, HTLV-1 infection may reduce cancer of the stomach to send sick into death danger.

　　 Does danger of cancer of the stomach reduce a mystery where to?

Matsumoto after announcing afore-mentioned discovery, of course won't at this point go no further, they also devote oneself to afore-mentioned seeing to announce be like the essence of cause and effect that has the phenomenal backside that is contrary to to often manage. In their paper, investigator puts forward, the effect that HTLV-1 reduces risk of cancer of the stomach may adjust with its active of pylorus screw bacterium is relevant.

Already numerous research evidence confirms, pylorus screw bacterium affects the important and critical factor that is cancer of the stomach. 1994, world Health Organization maintain, already enough epidemiology and histology evidence show, pylorus screw bacterium is the clear pathogen that cause cancer. Scholars had noticed, delicate concern exists between HTLV-1 and infection of pylorus screw bacterium. American Situfu (the report such as Stuver) , HTLV-1 is electropositive person enteron ulcer history remarkable less. British Walker (Walker) report, rate of infection of bacterium of screw of pylorus of the person that HTLV-1 is affected is inferior. Of Japan establish a flower (the report such as Tachibana) , late hair style of the person that healthy HTLV-1 is carried exceeds quick reaction is remarkable and abate, the person that although health is carried,hint also exists inferior clinical immunity is restrained. Accordingly, during HTLV-1 is affected for a long time, immune low-key progress may make gastric ministry forms the small environment that does not fit pylorus screw bacterium to decide breed, make its progressively from keep clear of inside the stomach.

Accordingly, the speculation such as Matsumoto, HTLV-1 infection reduces danger of cancer of the stomach and infection of pylorus screw bacterium to suffer related curb. In research, they observe really, no matter be the male, female overall still and character, this virus is electropositive person positive of pylorus screw bacterium is led under negative person, although this is planted,difference did not amount to significance. They notice, HTLV-1 infection antedates normally infection of pylorus screw bacterium, former 70% happen at Mu Ying perpendicular infection, after that person only 3% happen at 1 year old previously. The immunity that inchoate HTLV-1 infection may weaken gastric mucous membrane is respondent, affected infection of pylorus screw bacterium and hyperplasia thereby, also reduced risk of cancer of the stomach accordingly.

　　 HTLV-1: Does eulogy Qian collect  " ?

Does the interaction between HTLV-1 and infection of pylorus screw bacterium have He Yiyi after all? To this problem, the commentary that the corresponding period of J Infect Dis matchs to send offerred a few point of views, your person is read rise be full of interest.

The lay mines of college of medicine of university of American new York lustre (Blaser) go out in commentary middle finger, small possibility shows incidence of a disease of cancer of the stomach of the person that HTLV-1 is affected, this virus infection is a mark merely, show host is put in some kind of character originally, make this virus feels easily, can reduce cancer of the stomach to send; of sick into death danger to hint possibly also at the same time at the same time, HTLV-1 infection can offer some kind of cancer of the stomach to protect a mechanism. Evidence makes clear, latter nears Yu Zhen phase more, because HTLV-1 can restrain infection of pylorus screw bacterium.

Look from tumor biology angle, this kind of interaction of HTLV-1 and pylorus snail bacili has important sense, clew HTLV-1 may be a kind of accrete virus of human body, can pass the pathology process with revulsive bacterium of influence pylorus screw to protect host. Be in early 19 centuries, people has realized the value with human body microbial accrete, but till today, we just begin to understand its extensive sex and complexity. Long-term since, the attention of people is centered at bacterium of human body accrete, but whether to put in accrete virus to appear to human body lack person make inquires.

People pays close attention to all sorts of virus to carry the inflammation that cause, tumour for a long time to wait all the time, be like virus of EB virus, afterbirth of large and small, also include HTLV-1, and the research that wait put forward Matsumoto a such problems: " joint of bones of pacify raw meat or fish owes Lian  money not to cave divide evenly eulogy thoroughfare favour? looks from this angle, matsumoto the research it may be said that wait is " model " , they are microbial to what exist generally the long-term biology interaction between undertook exploration, in order to clarify its mutual between clinical cooperate with and antagonism action. If we continue to study human body deep inside " biology diversity " , we can discover the clinical value of this kind of interaction increasingly.

(responsibility edits: Chen Lu)