The dependence of the cell inside prostate to androgen each are not identical, cancer cell great majority relies on androgen, can make adult prostate epithelial and atrophic when androgen level falls, also can make prostate cancer cell has similar change. Be based on the endocrine therapeutics of this bit of generation just about, its core is refuse androgen treatment. Hide a gender as a result of prostate cancer shape strong, in when reason discovers, already was being entered more terminal, the foundation that in restraining the endocrine therapeutics of androgen to be become, cancer treats terminal prostate.

Current, endocrine cure regards the serious treatment of prostate cancer as the method, be in clinical on application is very wide. Its treat a method to basically include estrogen of spermary excision, application, androgen Jie to fight agent cure, corpus luteum to generate element to release hormone therapeutics and endocrine combination therapy to wait.

1. Spermary resection male sex hormone can make hyperplasia of prostate cancer cell active, reason can be used bilateral spermary resection cure. Spermary excision can make serum Gao ketone is overcome from 500 accept / cent rises (Ng/dI) falls to be overcome to 50 accept / cent rises (Ng/dl) , prevented great majority effectively to depend on androgen prostate thereby cancerous metabolization, make cancerous subsidise. The likelihood after spermary resection appears clonic calorific, perspire, impotent etc. Clinical and commonly used at prostate cancer person of terminal move carninomatosis, 5 years of survival rate after art are 31% , have transferrer for 20% , the advantage of spermary resection is can the main source of the androgen inside purify body, do not increase another kind of hormone inside body, the side-effect such as pathological changes of the anaemia that after taking estrogen, appears, heart and vessels and occurrent liver function exhaustion, nonexistent patient cannot insist to take medical issue for a long time, can complete treatment.

2. No matter estrogen is natural can reduce Gao ketone level through axis of hypophysis sexual gland with complex estrogen, restrain hypophysis to release hurried corpus luteum to make hormone (LH) . Yi Kezeng adds sexual steroid to combine globulin, reduce the synthesis of ketone of the Gao inside spermary, increase hypophysis to urge lacteal element to secrete, reduce synthesis of the DNA inside prostate cell, make Gao ketone is achieved go Gao level. Affect the metabolization of prostate cell thereby, make gland body atrophic. The most commonly used medicaments is personal Xi female phenol, main side effect is mammary development, impotent, disgusting, vomiting to wait, large dose can cause cardiovascular complication.

3. Combatting androgen medicaments main effect is to prevent androgen action at target cell, restrain the DNA synthesis of prostate nucleolus. Include steroid and blame steroid two kinds. His amine is fluorine the body that be not steriod kind fight androgen medicaments. His amine divides fluorine have outside fighting androgen action, without the action of any other hormone, side effect is accordingly less. Common have male breast Nancy or breast of mammary tenderness, excessive. His amine home already can produce fluorine, bring into cure to protect range.

4. Hurried corpus luteum releases hormone analogue (LHRH-A) can make Gao ketone and LH level elevatory in use initial stage, but application one week later level of ketone of LH, Gao begins to drop, 3 ～ can be achieved 4 weeks go Gao level, LHRH-A cure treats photograph comparing to have side effect with estrogen of profess to convinced the advantage of little, inadvertently hemal complication. Commonly used medicine is Buserelin, a month can achieve medicaments to go Gao, but home still cannot be produced, cost is high.

5. Because the cortin can restrain adrenal generation androgen,the cortin is treated, reason is used at treating prostate cancer, can improve general condition, can regard appeasement as therapeutics. Use lesser at present.

6. Endocrine combination therapy basically is to using remedy or androgen of origin of spermary of operation method purify while, with fight sluggish of androgen medicaments block the androgen of other source is right the action of cancer cell. Main program is bilateral spermary resection + fluorine his amine uses his amine or LHRH-A+ fluorine jointly. Inchoate application endocrine treats what can lengthen a patient to live jointly period. Clinical data had confirmed this kind of therapeutics showing curative effect. In a few typical anamnesis, the near future effect that this kind of endocrine combination treats is quite outstanding.

The element such as the risk that considers treatment, side-effect, charge and influence of opposite vivid quality, often list gland cancer patient before New Year to great majority, endocrine combination therapy is a kind of better cure choice.

(Responsibility edits: Liu Zhenlong)