Many clinical before data and anatomy, physiological to abdominal cavity the understanding that reachs ovarian cancer biology all hints, celiac and local give cellular noxiousness to medication ovarian cancer is very reasonable. Ⅰ period abdominal cavity changes the security that clinical trial confirmed cure to change cure medicaments and itself of the celiac technology that change cure, affirmed abdominal cavity changes cure to take the place of in medicine kinetic the advantage that go up.

Be in a few much centers Ⅱ period is clinical in the experiment, operation result confirms, about 20% ～ 40% accept second line in order to arrange platinum kind the celiac patient changing cure that is a foundation alleviates completely, accept before the  of <0.5 Cm of leftover cancer kitchen of this part patient with platinum kind the systemic systematization that is a foundation cure is effective.

In the research that changes cure in abdominal cavity, the Ⅲ that has 3 elaborate design period clinical trial result is the most significant.

1. The vein that arrange platinum gives medicine the comparison of the way to medicine and abdominal cavity:

Research brings into the patient of 2 Cm of ≤ of leftover cancer kitchen, the result shows, abdominal cavity can reduce tinnitus and neuter bead cell to reduce the occurence rate of disease to medicine, raise the occurence rate of bellyacke, lengthen a patient live period (abdominal cavity gives medicine to be opposite for 49 months to vein to medicine 41 months, p=0.02) .

2. Yew is mellow + the vein that arrange platinum gives medicine and suitable platinic abdominal cavity to give drug + yew mellow vein compares to medicine:

Research brings into the patient of 1 Cm of kitchen of the biggest leftover cancer, the abdominal cavity that arrange platinum accepts the Ka Bo of 2 period of treatment to change cure first to medical group patient, undertake to leftover cancer kitchen chemical sex tumour is decreased destroy. The result shows, arrange what platinic abdominal cavity gives medical group not to have progress to live period lengthen significantly (28 months are right 22 months) , overall live period also lengthen significantly (63 months are right 52 months) .

3. Yew is mellow + the vein that arrange platinum gives medicine and suitable platinic abdominal cavity to give drug + yew is mellow (vein + abdominal cavity gives drug) quite:

Mellow vein of the 1st day of yew gives test group drug, the 2nd day of abdominal cavity that arrange platinum gives drug, mellow abdominal cavity of the 8th day of yew gives drug, every period of treatment 21 days. The result confirms, abdominal cavity changes cure to be able to rise without progress survival rate.

These result of Ⅲ period test confirms, with the whole body the photograph that change cure is compared, the progress that the inject inside abdominal cavity suitable platinum regards a gleam of as to change cure plan to be able to make leftover cancer kitchen lesser period the recrudesce of ovarian cancer patient and mortality reduce 20% ～ 25% . But regretful is, researcher people oversight these important discovery, because suitable platinic meeting causes the undesirable reaction such as vomiting,this may be, so the doctor is not willing to carry out, the patient also is not willing to accept.

Reaction has the toxicity that turns cure to how reducing abdominal cavity to suggested at 2 o'clock:

1. Reduce the dosage of suitable platinum, decrease from 100 Mg/m2 to 75 Mg/m2;

2. Replace suitable platinum with Ka Bo, change in the abdominal cavity of ovarian cancer suitable platinum is being replaced with Ka Bo in cure is very reasonable, afore-mentioned Ⅰ period and the security that clinical trial already confirmed Ⅱ period to block platinic abdominal cavity to change cure and effectiveness.

The test that still needs to undertake at present is, to the ovarian cancer patient of kitchen of small leftover cancer, ka Bo abdominal cavity gives medicine and Ka Bo vein to part to change cure plan to undertake be comparatived directly as a gleam of to medicine. In future a few the middle of a month, association of tumour of American department of gynaecology (GOG) will start similar research, if this considers to be able to get " vein of the celiac excel that change cure changes cure " result, the remedial mode of patient of terminal and ovarian cancer will produce kitchen range of small leftover cancer change.

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